Fibroblast Growth Factor 2

A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Also Known As:

Basic Fibroblast Growth Factor; FGF 2; FGF2; Fibroblast Growth Factor, Basic; Cartilage-Derived Growth Factor; Class II Heparin-Binding Growth Factor; FGF-2; Fibroblast Growth Factor-2; Heparin-Binding Growth Factor Class II; Prostate Epithelial Cell Growth Factor; Prostatropin; Cartilage Derived Growth Factor; HBGF-2

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Fibroblast Growth Factors: 2575
      - Fibroblast Growth Factor 2: 5472
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Fibroblast Growth Factors: 2575
      - Fibroblast Growth Factor 2: 5472
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Fibroblast Growth Factors: 2575
    - Fibroblast Growth Factor 2: 5472

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Disease

Drug/Important Bio-Agent (IBA)